RENOVA (tretinoin emollient cream 0.05%) contains the same active ingredient as RETIN-A. It is a vitamin A derivative like the one naturally occurring in your body. But while RETIN-A is formulated for acne-prone skin, RENOVA is a rich emollient cream developed specifically for treating fine lines and wrinkles, brown spots, surface roughness and stretch marks that develop on the abdominal wall in women after pregnancy.

HOW DOES RENOVA WORK?
RENOVA-A works by binding to specific cell receptors of skin after a topical application. After the cellular receptors have been activated there is a modification in gene expression, subsequent protein synthesis and cell growth and differentiation. Thus, the epidermal cell is modified to produce a greater amount of new mature healthy skin. In clinical studies there is an enhanced production of collagen in areas of treated skin.

Unlike over-the-counter wrinkle creams that simply exfoliate the surface layer of skin, RENOVA is believed to work on all layers of the skin, including the epidermis, where pigmentary changes occur and even the deeper portions of the skin where fine wrinkling is thought to begin. Medical research has shown in published articles that RENOVA increases collagen. Researchers believe this is one way that RENOVA reduces the signs of aging.

HOW EFFECTIVE IS RENOVA?
In clinical studies looking at the efficacy of RENOVA 60% of patients treated for 24 weeks saw at least some decrease in fine facial wrinkling. The effect on coarse facial wrinkling, mottled hyperpigmentation, skin roughness, and laxity of the facial skin were less clear since the effect seen on each patient varied from study to study.

A study in the Archives of Dermatology, May 1996, showed that RENOVA cream significantly improved the appearance of early stretch marks. RENOVA worked best on stretch marks that were new or enlarging, such as those that develop during pregnancy.

HOW TO USE THIS MEDICATION:
RENOVA is for use on the face as directed, usually once a day at bedtime. Apply a pea-size amount of cream to clean, dry skin on the face being careful to avoid the eyes, nostrils and mouth. Wash your hands after use. Do not use this medication more often than prescribed or in larger amounts. It will not give you faster or better results but will increase the risk of side effects. Do not use on sunburn or eczema or other serious skin conditions. Effects of this medication will be gradual with most improvement seen in the first 6 months of continued therapy. If used for acne the condition may worsen at first, and then improve.

RENOVA TIMELINE:
1-2 months: you notice smoother skin and a softer texture to your skin.

3-4 months: freckles and brown spots begin to fade. Fine lines and wrinkles begin to diminish. A rosier glow to your skin is obtained.

6 months: Benefits should be apparent with fewer wrinkles and smoother and more even toned skin.

DRUG INTERACTIONS:
Let us know on your medical history/personal profile of any nonprescription or prescription medications that you may be taking including isotretinoin, amiodarone, tetracycline or quinolone antibiotics, sulfa drugs or phenothiazines as they increase skin sensitivity to the sun. Also let us know if you are using minoxidil and any skin medication, soaps, cleansers, cosmetics, astringents or any facial products that may be drying or irritating to the skin (e.g., alcohol-containing facial products). Benzoyl peroxide should not be applied at the same time as this medication.

SIDE EFFECTS:
You may experience mild redness or stinging, itching, burning, skin scaling, peeling and dry skin the first several weeks as your body adjusts to RENOVA. If any of these effects continue or become severe, discontinue use.

WARNINGS:
Before taking this medication let us know on your medical history/personal profile if you have any pre-existing skin disorders or if you have any allergies. This medication increases your sensitivity to the sun. Limit sun exposure and avoid sun lamps. Use a sunscreen and wear protective clothing when outdoors. This medication should be used only when clearly needed during pregnancy. It is unknown if this drug is excreted into breast milk. Consult with your doctor before breast-feeding.